Yet many more applications await. One of the most actively investigated gene transfer vehicles and emerging platforms is that of adeno-associated virus (AAV). Simply put, AAV consists of a protein ...

For central nervous system (CNS) applications, attempts are being made to deliver AAV gene therapy directly to the brain parenchyma or the cerebrospinal fluid (CSF) space by intra-cisterna magna ...

When Robert Atchison and his colleagues at the University of Pittsburgh first stumbled across adeno-associated viruses (AAV) in 1965, they initially supposed they were merely defective byproducts ...