Research led by Christian Medical College in Vellore, India, has demonstrated the successful use of lentiviral vectors to ...

AAV vectors are used clinically to treat a number of rare inherited retina diseases, but also carry the risk of eliciting sight threatening ocular inflammation. Establishing how AAV-mediated ...

AAV = Adeno-associated virus ... through their innate ability to home to areas of inflammation. Restoration of the balance between proinflammatory and immunosuppressant cytokines through gene ...

adeno-associated virus (AAV), to deliver the gene for a specific enzyme into cells. The new gene therapy automatically ...

Some research has suggested systemic administration of AAV vectors can cause damage to liver cells and inflammation. Dyno's AAV platform, called CapsidMap, uses artificial intelligence to improve ...

The client wanted to quickly determine whether their AAV vector could transduce RPE cells and whether transduction effectiveness was dose-dependent. Taking all project-specific aspects into ...

Existing gene therapies have primarily used a small number of naturally occurring AAV vectors limited by low delivery efficiency as well as problems with pre-existing immunity and manufacturability.

"Our gene therapy based on AAV-FGF21 can be transformative for patients ... associated steatohepatitis (MASH), characterized ...

Ntrust-2, a multi-center clinical trial, will evaluate NKX019 across three parallel cohorts, including patients with systemic sclerosis (SSc, scleroderma), idiopathic inflammatory myopathy (IIM, ...

AAV = Adeno-associated virus ... through their innate ability to home to areas of inflammation. Restoration of the balance between proinflammatory and immunosuppressant cytokines through gene ...