“The tropism of natural AAV serotypes is limited,” he says. “They also tend to infect the liver, which can cause severe side effects in some cases.” Improving AAV tropism could offer ...

2). The company is proceeding with additional capsid campaigns derived from AAV9, AAV5, and other AAV serotypes to identify novel capsids optimized for AAV delivery for specific therapeutic ...

In fact, a variety of AAV serotypes can be used to achieve different tissue tropism, efficacy and drug delivery effects. Due to their diversity, and the need to remove process-related impurities, the ...

The kit is developed to be serotype-specific, covering types 2, 5, 8, and 9, which are common in AAV therapies. This ...