Organoids were cultured from healthy donor iPSC sources and differentiated using the human iPSC-derived Cerebral Organoid ...

Danish start-up Fuse Vectors has received $5.2 million in preseed financing to further develop their gene therapy technology.

4 For instance, different AAV serotypes are better able to transduce particular tissue types, such as AAV12 into salivary gland cells. 5 Additionally, different combinations of payloads and vectors ...

In fact, a variety of AAV serotypes can be used to achieve different tissue tropism, efficacy and drug delivery effects. Due to their diversity, and the need to remove process-related impurities, the ...

with 1011 vg of eGFP transgene-bearing AAV5 WT as a negative control or using optimized AAV serotypes containing IVB-1 and IVB-2. Organoids were incubated at 37 °C 5 % CO 2 in all cases.

This approach, thanks to its easy applicability to multiple AAV serotypes, reduced processing steps, and comparable genome recovery rates, seems well-positioned to edge out immunoaffinity ...

2). The company is proceeding with additional capsid campaigns derived from AAV9, AAV5, and other AAV serotypes to identify novel capsids optimized for AAV delivery for specific therapeutic ...

“The tropism of natural AAV serotypes is limited,” he says. “They also tend to infect the liver, which can cause severe side effects in some cases.” Improving AAV tropism could offer ...

the addition of the new kits for serotypes AAV2 and AAV8 extends the range’s suitability to approximately 70% of the AAV gene therapy market, with AAV2 being the most prevalent serotype in clinical ...