Adenoviral vectors will transduce a wide range of target cells resulting in high-level gene expression. They are non-integrating vectors so expression in dividing cells is progressively lost. First ...

This vector could be amplified in fiber receptor ... activity explains the resistance of ciliated airway epithelia to adenovirus infection. J. Clin. Invest. 100, 1144–1149 (1997).

Ad5 vectors are the most commonly used adenovirus vector. Ad5 vectors transduce a wide range of cell types. They utilize the Coxsackie-Adenovirus Receptor (CAR) to enter cells. Transduction efficiency ...

To overcome this limitation we have developed an adenoviral vector that can deliver regulated gene expression in response to physiological stimuli. A large number of pathological conditions are ...