The universal cell-cycle inhibitor p21 Cip1/WAF1 is phosphorylated ... as a result of its physical association with the oncogenic Akt protein. Subcellular mislocalization of checkpoint controllers ...
AstraZeneca has claimed FDA approval for its first-in-class pan-AKT inhibitor capivasertib, getting a green light for the drug as a treatment for breast cancer, but with a more restrictive label ...
In amongst a clutch of discontinued phase 3 programmes in Roche's fourth-quarter results update was the news that it has stopped a study of AKT inhibitor ipatasertib as a treatment for first-line ...
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