A stable interaction between antigen-presenting cells (APC) and T cells is dependent not only on the absolute affinity between the T-cell receptor (TCR) and its ligand but also on the relative ...

Indeed, several groups have reported that overexpression of axin in APC-mutant cancer cells effectively reconstitutes the function of the destruction complex, indicating that there is no absolute ...

To isolate immune cells, Lanna and his collaborators derived T cells and APC cells from the blood of human research participants, then cultured these cells. Then they exposed the cells to a mixture of ...

Colon cancer has been on the rise in Americans under 50 for the last three decades, but it’s not exactly clear why.

E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...

A gene called high mobility group A1 (HMGA1) may be the key that opens the door to the development of colon cancer, according ...

The police were finally able to get him into a set of Smith & Wesson designer bracelets when the APC stalled on its way to knock out yet another cell tower. Sounds like someone might have ...

Update: This story was updated to correct the name of the telecommunications service provider to APC Towers. FRANKFORT — Construction on a new communications tower has begun on land owned by the city ...

In the nucleus, β-catenin activates downstream genes like c-Myc and Cyclin D1, promoting cell proliferation and survival. In HCC, mutations in key components of the Wnt pathway, including β-catenin ...