Beta-blockers antagonize beta-1 and beta-2 receptors ... decreases the propagation of action potentials. This is also the mechanism that local anesthetics work (lidocaine). Class I antiarrhythmic ...

Beta blockers have been shown to prolong survival ... progressive ventricular remodeling may be the critical mechanism leading to an impairment of ventricular function already at rest.

Successful therapy not only needs to be effective, it also needs to be well tolerated. β-blockers are well established as effective antihypertensive agents. However, one major drawback to the ...