脂肪组织与中枢神经系统之间存在复杂的通信机制，以维持全身能量稳态。传统观点认为，脂肪组织通过分泌循环激素向大脑传递代谢状态信息，而大脑则通过交感神经输出调节脂肪细胞功能。背根神经节（DRG）的感觉神经元也被证实支配脂肪组织，但其生理重要性因缺乏特异性 ...

One interesting alternative is the recent advent of methods for the use of gene therapy vectors that are injected intravenously. AAV9 is known to have some natural ability to penetrate the blood-brain ...

Researchers reveal that the loss of mucin-type O-glycosylation in the brain endothelial glycocalyx weakens the blood-brain ...

引言在人类大脑的微观世界中，一道厚度不足头发丝百分之一的生物屏障——糖萼（细胞周基质）（glycocalyx），正悄然主导着一场关乎生死的防御战役。2月26日《Nature》的研究报道“Glycocalyx dysregulation impairs blood–brain barrier in ageing and ...

通过对正常肝脏和脂肪肝肝脏的比较，研究人员发现，脂肪肝对AAV载体的转导效率和特异性有显著影响，不同AAV载体的转导表现也因病理状态的不同 ...

Organoids were cultured from healthy donor iPSC sources and differentiated using the human iPSC-derived Cerebral Organoid ...

It ensures that the brain has access to key nutrients while protecting it from pathogens and toxins. On the flip side, the BBB blocks many promising therapeutics. However, system upgrades to the ...

Compared to naturally occurring AAV serotypes, Latus’ capsids transduce the NHP brain with greater tropism, using signficantly lower doses and injection volumes. Data are bolstered by in vitro ...

1 Indeed, last November the FDA approved PTC Therapeutics’ Kebilidi, the first U.S. gene therapy to be administered directly into the brain. 2 The AAV-based therapeutic treats a rare fatal ...

With Latus’ game-changing capsid, AAV-DB-3, we plan to develop a one-time treatment that aims to deliver potentially definitive therapy to the regions of the brain that are most affected in HD,” says ...