Ampicillin (alpha-aminobenzyl penicillin), the first of the semisynthetic penicillins to provide increased activity against gram-negative bacteria, was prepared by Doyle et al. 156 It is of ...

Traditionally, antibiotics have come from natural sources, for instance penicillin, or are modified to achieve broad-spectrum activity. Using a so-called ‘lock and key’ mechanism at the ...

Conclusion. Ceftobiprole is a novel, broad-spectrum, parenteral cephalosporin undergoing Phase III clinical trials. Its broad spectrum of activity makes it a candidate for monotherapy of cSSSIs ...