The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

5B). MIP-1α specifically bound to CCR5-expressing cells and not to control cells expressing another chemokine receptor, CXCR4. The binding of radiolabeled MIP-1α to the CCR5-expressing cells was ...

Other targets for entry inhibitors include two co-receptors on the cell surface—CCR5 and CXCR4—which together with CD4 mediate virus binding and membrane fusion 3. As CCR5, but not CXCR4 ...

The discovery of HIV coreceptors, such as CCR5 and CXCR4, has prompted a search for inhibitors against these receptors as an alternative therapy to HAART. Although new anti-HIV drugs that target ...