We first studied the effects of high- fat diet (HFD) on Cd28KO, then on wild-type (WT) mice treated with an inhibitor of CD28/B7 interactions, CTLA4-Ig. We report that Cd28KO displayed larger ...

It is a key co-stimulatory molecule required for T cell activation. CD28 serves as the receptor for CD80 (B7.1) and CD86 (B7.2). When antigen-presenting cells (APCs) are activated by Toll-like ...