TAB08 is a mAb that targets the key co-stimulatory receptor CD28 on T lymphocytes. Unlike with other drugs, binding of TAB08 to CD28 allows direct activation of T cells with only tonic T cell ...

When the researchers treated the mice with OKT3 or another monoclonal antibody, anti-CD28, they found that human cytokine levels varied across the 10 donors. For example, the PBMC humanized mice ...