TAB08 is a mAb that targets the key co-stimulatory receptor CD28 on T lymphocytes. Unlike with other drugs, binding of TAB08 to CD28 allows direct activation of T cells with only tonic T cell ...

T-cell-specific surface glycoprotein CD28, also known as TP44, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. It is a key co-stimulatory ...

When the researchers treated the mice with OKT3 or another monoclonal antibody, anti-CD28, they found that human cytokine levels varied across the 10 donors. For example, the PBMC humanized mice ...

a novel CD28 x Nectin-4 costimulatory bispecific antibody for advanced bladder cancer, is being presented in a poster session at the 2025 American Society of Clinical Oncology (ASCO) Genitourinary ...