Immunofluorescent staining of the T cell marker CD3 (green), the Treg marker Foxp3 (red) and the nucleus (blue). The cold treatment results in a significant increase of Foxp3 expression in T cells.

Notably, IFT20 clusters with TCRs at the immune synapse and associates with the ζ- and ɛ-chains of CD3 in response to TCR engagement. TCR–CD3 complex assembly is initiated in the endoplasmic ...