Notably, IFT20 clusters with TCRs at the immune synapse and associates with the ζ- and ɛ-chains of CD3 in response to TCR engagement. TCR–CD3 complex assembly is initiated in the endoplasmic ...

在免疫学中，标记分子是用于识别和分类不同免疫细胞类型的重要工具。尽管有些分子的名称相似，但它们在结构和功能上有细微差别。下面我们将详细解析常见标记分子及其差异，帮助你更好地理解它们在免疫系统中的作用。

中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）许琛琦研究组联合上海科技大学王皞鹏研究组，在 Immunity 期刊发表了题为 Phase separation of chimeric antigen receptor ...

T cell activation requires a T cell receptor (TCR) to recognize its cognate peptide in the context of an MHC molecule. In addition, the association of CD3 with the TCR–peptide–MHC complex ...

前两年ADC的火爆，不仅打开了国内Biotech的视野，也让MNC全面地了解了中国创新药发展的丰富性。在ADC之后的下一个风口TCE双抗全面爆发前夜，MNC迅速锁定目标，果断出手，于是我们看到了今年下半年以来暴风骤雨般的License-out。事实上 ...

▎药明康德内容团队编辑 嵌合性抗原受体（Chimeric antigen receptor,  CAR）是一种人工合成的免疫受体，整合了抗体的抗原识别区，T细胞抗原受体（T cell receptor, ...

Image Credit: ACROBiosystems CD3 molecules tend to bind to TCR non-covalently to develop a TCR/CD3 receptor complex on the T-cell’s surface. There are four subtypes of CD3 — CD3ε, CD3δ ...

that consists of a soluble TCR targeting gp100 expressed on cancer cells fused to a protein that binds CD3 receptors on lymphocytes – as a treatment for unresectable or metastatic uveal melanoma.

11月27日，国际学术期刊Immunity在线发表了中国科学院分子细胞科学卓越创新中心 (生物化学与细胞生物学研究所)许琛琦研究组联合上海科技大学王皞鹏研究组的最新合作成果：“Phase?separation of chimeric antigen receptor promotes immunological synapse?maturation and ...

Cost-effectiveness agency NICE has recommended NHS use of the therapy, called Kimmtrak (tebentafusp), for the treatment of ...