中国科学院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)许琛琦研究组联合上海科技大学王皞鹏研究组,在 Immunity 期刊发表了题为 Phase separation of chimeric antigen receptor ...
▎药明康德内容团队编辑 嵌合性抗原受体(Chimeric antigen receptor,  CAR)是一种人工合成的免疫受体,整合了抗体的抗原识别区,T细胞抗原受体(T cell receptor, ...
Notably, IFT20 clusters with TCRs at the immune synapse and associates with the ζ- and ɛ-chains of CD3 in response to TCR engagement. TCR–CD3 complex assembly is initiated in the endoplasmic ...
T cell activation requires a T cell receptor (TCR) to recognize its cognate peptide in the context of an MHC molecule. In addition, the association of CD3 with the TCR–peptide–MHC complex ...
前两年ADC的火爆,不仅打开了国内Biotech的视野,也让MNC全面地了解了中国创新药发展的丰富性。在ADC之后的下一个风口TCE双抗全面爆发前夜,MNC迅速锁定目标,果断出手,于是我们看到了今年下半年以来暴风骤雨般的License-out。事实上 ...
Image Credit: ACROBiosystems CD3 molecules tend to bind to TCR non-covalently to develop a TCR/CD3 receptor complex on the T-cell’s surface. There are four subtypes of CD3 — CD3ε, CD3δ ...
在免疫学中,标记分子是用于识别和分类不同免疫细胞类型的重要工具。尽管有些分子的名称相似,但它们在结构和功能上有细微差别。下面我们将详细解析常见标记分子及其差异,帮助你更好地理解它们在免疫系统中的作用。
that consists of a soluble TCR targeting gp100 expressed on cancer cells fused to a protein that binds CD3 receptors on lymphocytes – as a treatment for unresectable or metastatic uveal melanoma.
11月27日,国际学术期刊Immunity在线发表了中国科学院分子细胞科学卓越创新中心 (生物化学与细胞生物学研究所)许琛琦研究组联合上海科技大学王皞鹏研究组的最新合作成果:“Phase?separation of chimeric antigen receptor promotes immunological synapse?maturation and ...