The strong allogeneic response to donor MHC molecules in transplantation and the weak response to tumor antigens represent two important and divergent but potentially interactive immune responses.
CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...
CD4+ and CD8+ T cells accumulate in the skin of patients with psoriasis. These cells are also identified by markers of activation (e.g., increased IL-2 receptors and HLA-DR surface molecules) and ...