Medical Xpress13d
Mouse model uncovers how lung cells manage severe asthma inflammation
Interestingly, the team also discovered that the epithelial cells try and control this inflammation by using a specialized ...
Nature9y
Preclinical targeting of human T-cell malignancies using CD4-specific chimeric antigen receptor (CAR)-engineered T cells
Here we have designed a CAR, CD4CAR, which redirects the antigen specificity of CD8+ cytotoxic T cells to CD4-expressing cells. CD4CAR T cells derived from human peripheral blood mononuclear cells ...
EurekAlert!13d
A treatment-resistant, severe type of asthma successfully modeled in mice
When activated, one subset of CD4+T RM cells lining the airways produces ... this inflammation by using a specialized immune-facing molecule called MHC-II. They do so by using MHC-II to instruct ...