但当 CD8 存在时，情况则相反，更强的 3D 结合亲和力会降低 TCR 对同源抗原（如 R4-MHC）的敏感性和特异性，却增加对非刺激抗原（如 L4-MHC）的敏感性。这表明 CD8 与 TCR-pMHC 结合在调节 TCR 特异性上存在复杂的协同效应。 考虑到 TCR 与 pMHC 在二维（2D）质膜上结合 ...

CD8 + T cells can recognize and then kill HIV-infected cells following the presentation of fragments of viral proteins (epitopes) in the peptide-binding groove of MHC class I molecules on the ...

目前，MS 的发病机制仍是医学界亟待解开的谜题。已知它涉及针对髓鞘抗原的自身免疫反应，其中辅助性 T 细胞 4（CD4 + T 细胞），尤其是 Th1 和 Th17 亚群，在推动疾病进展中 “扮演” 着重要角色。然而，细胞毒性 T 细胞 8（CD8 + T 细胞）在 MS 和实验性自身免疫性脑脊髓炎（Experimental Autoimmune ...

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

The CD8-mediated binding can usually be blocked by inclusion of select CD8 monoclonal ... Prepare 2x staining cocktail containing all of your labeled reagents at the right titer. The suggested titer ...

Memorial Sloan Kettering Cancer Center researchers have found RNA neoantigen vaccines that generate long-lived, functional ...

Recipient T cells recognize donor antigens via two distinct pathways: the direct pathway (intact donor MHC molecules displayed on donor antigen-presenting cells [APCs]) and the indirect pathway ...