CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

CD8 + T cell exhaustion is defined by a unique transcriptional ... Here authors show that activation of the downstream WNK1 kinase causes water entry into the cells, which is essential for CD4 ...

"Understanding the fundamental rules of T cell activation could be a game-changer for immunology," Heath said. More information: Jingyi Xie et al, APMAT analysis reveals the association between CD8 T ...

Researchers have uncovered a previously unknown mechanism that regulates the immune response against parasites. During a parasitic infection, specific immune cells, known as virtual memory T cells ...

Upon initial activation by their cognate antigen, naïve CD8 + T cells start to proliferate and differentiate into short-lived effector and long-lived memory precursor cells. How a single ...

have published research in Nature Machine Intelligence introducing MUNIS-a deep learning tool designed to predict CD8+ T cell epitopes with unprecedented accuracy. This advancement has the ...

Discover a study that describes a host-intrinsic mechanism responsible for the failure of PD-L1 blockade in ovarian cancer.

Fapon Biopharma, a biotech innovator in developing therapeutic antibodies and fusion proteins, is pleased to announce that the U.S. Food and Drug Administration (FDA) has approved the Investigational ...