CD8 + T cell exhaustion is defined by a unique transcriptional ... Here authors show that activation of the downstream WNK1 kinase causes water entry into the cells, which is essential for CD4 ...

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

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Researchers have uncovered a previously unknown mechanism that regulates the immune response against parasites. During a parasitic infection, specific immune cells, known as virtual memory T cells ...

Upon initial activation by their cognate antigen, naïve CD8 + T cells start to proliferate and differentiate into short-lived effector and long-lived memory precursor cells. How a single ...

"Understanding the fundamental rules of T cell activation could be a game-changer for immunology," Heath said. More information: Jingyi Xie et al, APMAT analysis reveals the association between CD8 T ...

Discover a study that describes a host-intrinsic mechanism responsible for the failure of PD-L1 blockade in ovarian cancer.