a | The interaction of CTLA-4 on T REG with CD80 and CD86 on DCs transduces a negative signal to DCs that ultimately reduces the potential of DCs to stimulate naive T cells. b | In autoimmunity ...
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New strategy for safer CAR T cell therapy in lymphomasThe study, "An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL," was published in the journal Cell Reports Medicine. This strategy is ...
The inhibitory mechanism of action comes from the ability of these DC secreted CTLA-4+ EVs to bind to the co-stimulatory DC surface markers CD80 and CD86 to prevent T-cell activation. Therefore DC ...
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