CTLA-4 delivers inhibitory signals to DCs, resulting in the down-regulation of CD80 and CD86 expression on these cells. 1,2 T REG-specific deficiency of CTLA-4 impairs the in vivo and in vitro ...

In addition to binding the CD80 and CD86 receptors on the surface of antigen presenting cells, impairing their ability to activate T cells, the CTLA-4 receptor on T helper cells can physically snatch ...