Heike Pahl (Univ. Hospital, Freiburg, Germany) reported that expression of mutant CFTR induces NF-κB expression and activates transcription of the κB gene. Levels of the inflammatory cytokine ...

Individuals can inherit the mutant copy of the disease-associated ... gene disease associated with recessive mutations in the CFTR gene. However, more extensive studies of CFTR mutations in ...

Porosome Therapeutics, Inc. announced the Orphan Drug Designation of its cystic fibrosis therapy by the Food and Drug Administration (FDA).

Researchers introduced functional porosomes into the plasma membrane of CFTR mutant cells to demonstrate that porosome reconstitution normalizes mucus secretion more than twice as effective than ...

The first CF rat model, CFTR tm1sage (termed CFTR-/- or KO), was designed in collaboration with SAGE (now Horizon Discovery) and subsequently characterized at UAB and distributed to the CF community.

The CFTR Protein Distribution Core offers high-quality, full-length recombinant cystic fibrosis transmembrane conductance regulator (CFTR) proteins expressed in and purified from mammalian cells. Wild ...