2024 年 1 1 月 1 日， 我院天然药物及仿生药物全国重点实验室 田松海 研究员团队 在 著名期刊 Nature Protocols 发表了题为 “ Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins ” ...

In a bacterial cell, when it’s infected with a virus, the CRISPR system responds using its army of proteins. Some CRISPR proteins take a piece of the virus and insert it in the host genome ...

CRISPR-Cas9 has long been likened to a kind of genetic scissors, thanks to its ability to snip out any desired section of DNA ...

In nature, the best-known CRISPR system, CRISPR-Cas9, cuts any RNA or DNA it recognizes as foreign, and thereby protects bacteria from viral attacks. Another CRISPR system, one that is relatively ...

Various types of endonucleases – enzymes that can cut DNA – were already known before CRISPR-Cas9. The discovery of restriction enzymes in the early 1970s heralded a new age in molecular biology.

CRISPR-Cas9 has two components. The first is an enzyme—Cas9—that functions as a cellular scalpel to cut DNA. (In nature, bacteria use it to sever and disarm the genetic code of invading viruses.) ...

So why do we call it CRISPR? Cas proteins are used by bacteria to destroy viral DNA. They add bits of viral DNA to their own genome to guide the Cas proteins, and the odd patterns of these bits of ...

Using a genome editing tool known as Crispr, US scientists inserted a gif - five frames of a horse galloping - into the DNA of bacteria. Then the team sequenced the bacterial DNA to retrieve the ...

It acts as a sort of molecular fumigator to battle phages and plasmids. CRISPR-Cas9 has long been likened to a kind of genetic scissors, thanks to its ability to snip out any desired section of ...

The CRISPR molecular scissors have the potential ... complex that plays an important role in the immune defense against bacteria and molds. The research team has now succeeded in using the CRISPR ...