The CRISPR-Cas gene scissors offer a wide range of potential applications, from the treatment of genetic diseases to antiviral therapies and diagnostics. However, to safely harness their powers, ...

The CRISPR-Cas gene scissors offer a wide range of potential applications, from the treatment of genetic diseases to antiviral therapies and diagnostics. However, to safely harness their powers, ...

Subsequently, the CRISPR array is transcribed into a long precursor crRNA, which is further processed into the mature crRNA by Csy4 protein. Finally, this stable Csy4-crRNA complex subsequently ...

Efficient and site-specific genome engineering can be achieved based on programmable nucleic acid cleavage using CRISPR-Cas surveillance complexes. Structure-function studies on single component Cas ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.

With CRISPR-Cas9, the crRNA/tracrRNA sequence or an artificial guide RNA indicate where the DNA can be cut. It is relatively easy for scientists to produce different sequence variants from RNA ...

The CRISPR locus is transcribed and processed to generate mature CRISPR RNAs, each encoding a unique spacer sequence. Each crRNA associates with Cas effector proteins that use crRNAs as guides to ...

CRISPR Therapeutics AG is a gene editing company, which engages in the development of transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform.

The results were published in the journal Molecular Cell ("AcrVIB1 inhibits CRISPR-Cas13b immunity by promoting unproductive crRNA binding accessible to RNase attack"). Bacteria and their viruses, ...