CRISPR-Cas9筛选技术在肿瘤学领域的应用已经取得了显著进展。通过构建全基因组敲除文库，研究者可以系统地鉴定出驱动癌症发生发展的关键基因。例如，研究者可以通过CRISPR-Cas9技术在肿瘤细胞中进行基因敲除，筛选出对肿瘤生长和转移至关重要的基 ...

如今，在一项新的研究中，洛克菲勒大学细菌学实验室的Luciano Marraffini及其团队和纪念斯隆-凯特琳癌症中心结构生物学实验室的Dinshaw Patel及其团队发现一种CRISPR系统不仅能用基因剪刀对付入侵者，还能充当某种分子熏蒸剂。相关研究结果近期发表在 Cell 期刊上，论文标题为 “The CRISPR-associated adenosine deaminase Cad1 ...

UCSF Benioff Children's Hospital Oakland is enrolling patients in an innovative clinical trial that seeks to cure sickle cell ...

This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The ...

The complexity of the central nervous system (CNS) and its pathologies necessitates an intricate understanding of the cellular and molecular mechanisms at play. Single-cell biology has emerged as a ...

UCSF Benioff Children’s Hospital Oakland is enrolling patients in an innovative clinical trial that seeks to cure sickle cell ...

A review discussing the therapeutic potentials of NK cell biology has been published in the journal Frontiers of Medicine.

Memorial Sloan Kettering Cancer Center-led researchers have identified a small molecule called gliocidin that kills ...

By targeting the TTR gene directly in the liver, the therapy “has opened up the door” to permanent treatment, says Sarah ...

(see more details here) A laboratory cultivating cells for the development of gene and cell therapies. CRISPR Therapeutics AG ...