它作为一种分子熏蒸器来对抗噬菌体和质粒。 长期以来，CRISPR-Cas9一直被比作一种基因剪刀，因为它能够精确地剪掉任何想要的DNA片段。 但事实证明，CRISPR系统的工具箱中有不止一种策略。CRISPR最初是在细菌中发现的一种机制，它作为一种适应性免疫系统已经 ...

In any event, the scientists’ finding indicates that CRISPR-Cas systems employ a wide range of molecular mechanisms beyond nucleic acid degradation to provide adaptive immunity in prokaryotes.

When developing a drug, it’s important to understand its target and its mechanism of action. This is particularly crucial when repurposing an abandoned asset from another indication. CRISPR ...

CRISPR/Cas9 is a gene editing tool that has revolutionized biomedical research and led to the first FDA-approved CRISPR-based gene therapy. However, until now, the precise mechanism of exactly how ...

Researchers in Lithuania present the molecular structure of a new, more-versatile CRISPR system for gene editing.

CRISPR/Cas9 is a gene editing tool that has revolutionized biomedical research and led to the first FDA-approved CRISPR-based gene therapy. However, until now, the precise mechanism of exactly how ...

CRISPR-Cas9 can elegantly and precisely cut away any desired region of DNA and has long been compared to a type of genetic ...

Rotten tomatoes no more: growing sweeter tomatoes is possible by editing just two of the fruit’s genes. Deleting the genes ...

This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The ...