Figure 2: Human APC and CTNNB1 mutations are associated with carcinogenesis. Figure 3: Cancer therapeutics that target components of the canonical Wnt pathway. Recent studies suggest that so ...

CTNNB1 Syndrome is a rare neurodevelopmental disorder caused by mutations in the CTNNB1 gene, which plays a critical role in brain development and function. Symptoms include developmental delays ...

First identified in 2012, CTNNB1 syndrome affects an estimated 1 in 50,000 people worldwide. It is not inherited from parents ...

Patients with CTNNB1 Syndrome will benefit from this joint effort to develop and manufacture a new AAV investigational gene therapy, which aims to restore gene function and may improve quality of ...