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14 天
时空转录组学揭示了暴发性病毒性心肌炎的发病机制
心肌炎多由病毒感染引发,如 CVB3、细小病毒 B19 等,近年来,抗肿瘤药物和 COVID - 19 的流行使心肌炎发病率和死亡率上升。暴发性心肌炎(FM)是心肌炎的最严重形式,起病急骤、进展迅速,常导致心脏功能障碍、恶性心律失常甚至猝死。FM 的发病机制涉及病毒直接损伤和免疫介导损伤,但具体免疫机制尚不明确,这给疾病的诊断和治疗带来挑战。
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