Aims Clopidogrel is the most commonly prescribed thienopyridine as part of dual anti-platelet therapy for the treatment of ...

DONCASTER and Bassetlaw Teaching Hospitals has been named as one of just four NHS sites in England selected to test a new ...

PPIs, especially omeprazole and esomeprazole, rely on the cytochrome P450 2C19 (CYP2C19) enzyme for processing and inhibit it. Asians also are genetically slower CYP2C19 metabolizers which may ...

Omeprazole, the prototype drug of PPIs, is metabolized primarily by CYP2C19 to 5-hydroxyomeprazole. 5-hydroxyomeprazole is then transformed into 5-hydroxyomeprazole sulfone by CYP3A4. Omeprazole ...