Some of the most widely used drugs today, including penicillin, were discovered through a process called phenotypic screening ...

Because DCP-001 cells are derived from a cancer cell type they express multiple tumor-associated antigens, but with a mature dendritic cell phenotype. These antigens have been shown to overlap ...

Malignant cells down-regulate cell death by overexpressing a transcription factor called BCL6. “Our idea was to borrow a little bit of the activity of the kinase and drag it over to where BCL6 is ...

Neuroscientists have uncovered a mechanism that controls the reactivation of neural stem cells, which are crucial for ...

Breast cancer cells, when disseminated to other secondary organs such as the lungs, may stay in a dormant state for years, even decades. But the mechanisms that limit their expansion are not well ...

Instead of going from tumor cells to fat cells, in muscle-invasive bladder cancer, the combination therapy ... tumor shifts from the basal/squamous phenotype to the luminal phenotype." ...

A research paper published in Nature Cancer details ... the engulfment of dead cells acts as a key driver to reprogram ...

Researchers developed novel genetic tools to trace, ablate, and manipulate p16^Ink4a+^ senescent cells, revealing their ...

Pancreatic cancer is one of the deadliest diseases in United States ... the oncogene also increased cell proliferation through a PKA- independent pathway, demonstrating a cell-type specific phenotype ...

We are combining patient data biocomputing analysis with cell-based and animal experiments to determine the networks of RNA regulation that governs the phenotype of breast cancer metastasis. In ...

Modifying a protein that controls cell growth can reactivate dormant neural stem cells in fruit flies which could help ...