上述结果表明，自体抗CD7 PEBL-CAR T细胞具有强大的抗白血病活性，是治疗T-ALL的潜在有效选择。这也意味着抗CD7 PEBL-CAR T细胞能够克服限制当前复发或难治性T-ALL治疗的耐药机制，为患者带来希望。

近期，该研究团队在 Nature Medicine上发表了题为 Fratricide-resistant CD7-CAR T cells in T-ALL的论文， 报告了17例接受自体抗CD7 PEBL-CAR T细胞治疗的T-ALL患者的 ...

The first base edit disabled the T-cells targeting mechanism so they would not assault Alyssa's body The second removed a chemical marking, called CD7, which is on all T-cells The third edit was ...