Subcellular mislocalization of checkpoint controllers is now surfacing as a mechanism of deregulating cell proliferation in cancer. Figure 1: Oncogene Her2/neu-initiated, Akt-mediated p21 Cip1 ...

Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for ...

A review discussing the therapeutic potentials of NK cell biology has been published in the journal Frontiers of Medicine.

Non-transformed cells depend on growth factor signaling to direct glucose and glutamine uptake ... We have demonstrated that in human and mouse cancer cell lines, activated Akt directs a direct ...

Natural killer (NK) cells play an important role in the innate immune response to cancer and viral infections, and their ...

The results showed that cordycepin significantly inhibited growth factor signaling in multiple cell lines, particularly through the MEK/ERK and PI3K/AKT/mTOR pathways. This inhibition was observed ...

Skeletal muscle tissue demonstrates global hypermethylation with aging. However, methylome changes across the time-course of ...