Objective: The purpose of the present study was to demonstrate clinical equivalence between the application of collagenase ointment at 24- and 48-hour intervals in the healing of pressure ulcers.

Oral informed consent was obtained from all patients. All patients were entered into an active run-in period with collagenase ointment (Iruxol® Mono, Laboratorios Knoll, SA, Madrid, Spain ...

We have examined various possible methods for avoiding these difficulties and have found that the substitution of collagenase for trypsin satisfied most of our requirements.