these culminated in the International Knockout Mouse Consortium (IKMC) in 2007 with the aim to establish knockout and conditional mouse strains for all mouse genes. This article traces the origins ...

Gene-expression analysis showed that in Lrf-conditional-knockout mice the expression of several factors involved in the early B-cell developmental programme was downregulated in the pre-pro-B cells.

The first direction is to elucidate the functional mechanism of Myrf, a key transcription factor for CNS myelination. Conditional knock-out mice in which Myrf is knocked out in the OL lineage cells ...

We have observed implantation defects and thus, reduced fecundity in conditional knockout mice models of the autophagy-related proteins in the reproductive tract. In the absence of these proteins, we ...

Express a human CFTR-W1282X transgene from the intestine-specific FABP promoter on the Cftr tm1Cam knockout background. Mouse lines carrying a conditional null allele of Cftr (Cftr10 fl) or a ...