Zoom in of the mechanism: The RNA binding (in blue) flips the switch of the CRISPR-Cas system (in green), which activates its cutting mechanism. Disclaimer: AAAS and EurekAlert! are not ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

Dec. 4, 2024 — Researchers have uncovered a serious side effect of using the CRISPR-Cas gene scissors. A molecule designed to make the process more efficient destroys parts of the ...

YouTube Link: https://youtu.be/FzTmlMCUDcI Columbia University Medical Center (CUMC) and University of Iowa scientists have used a new gene-editing technology called ...

This gene-editing tool has been adapted for molecular diagnostics, utilizing Cas proteins to detect specific nucleic acid sequences with high sensitivity. CRISPR-based platforms such as SHERLOCK ...

The microbes that make up an organism’s microbiome have a range of effects on its health. Scientists use CRISPR systems to genetically manipulate specific bacterial species, for instance those found ...

Yet others, called base editors, change one letter of the DNA code to another. So why do we call it CRISPR? Cas proteins are used by bacteria to destroy viral DNA. They add bits of viral DNA to ...

This work is published on bioRxiv in a preprint titled, “Single-AAV CRISPR editing of skeletal muscle in non-human primates with NanoCas, an ultracompact nuclease.” NanoCas is a novel Cas ...

ultracompact CRISPR system delivered via a single AAV vector This study describes the discovery, engineering and benchmarking of NanoCas – a novel Cas enzyme approximately one third the size of ...