人工智能基础模型的出现，为生物序列建模指明了一条有前景的道路，但尚未实现全基因组水平的建模。DNA序列非常长，例如我们人类有着30亿碱基对，简单如大肠杆菌也有这数百万碱基对。要想充分理解进化的影响，需要具有单个核苷酸分辨率的分辨率，这些问题使得大规模 ...

【导读】 就在刚刚，AI设计DNA、RNA和蛋白质序列的能力再获得颠覆性突破，研究登上Science封面。Evo模型能以无与伦比的准确性，解码和设计从分子到基因组规模的对象了，合成生物学的工作方式，从此或将彻底颠覆。

The genome-editing technology can be supercharged by artificial intelligence—and the results are already being felt.

2024 年 1 1 月 1 日， 我院天然药物及仿生药物全国重点实验室 田松海 研究员团队 在 著名期刊 Nature Protocols 发表了题为 “ Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins ” ...

CRISPR/Cas9 Modifies Euglena to Create Potential ... Researchers Develop DANGER Analysis Tool for the Safer Design of Gene Editing Oct. 23, 2023 — A team of researchers has developed a software ...

This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The ...

Scientists used Crispr—a tool that can modify DNA—to boost the sugar content of bland plants.

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.

CRISPR Therapeutics AG is a gene editing company, which engages in the development of transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform.

Presentations will showcase the company’s latest advances enabled by its CRISPR by Design TM approach to engineer safer and more effective in vivo genetic medicines for cardiometabolic disease ...