While Cas9 has been the predominant enzyme in CRISPR applications over the past decade, Cas12a offers advantages. “In contrast to Cas9, Cas12a can delete multiple genes at the same time with ...

Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

The researchers were also able to identify genes that led to accelerated lymphoma growth in the pre-clinical model by using unique Cas12a-compatible mouse whole-genome CRISPR "libraries".

1). CRISPR–Cas12a has a low tolerance for base-pair mismatches between the crRNA and the DNA target sequence. Ensoma applied its knowledge of the protein’s structure to further hone ...

Despite its successes, the CRISPR-Cas9 system has several limitations, including off-target cutting. Over the years, scientists have explored alternatives to Cas9, such as Cas12a for more precise ...

The researchers were also able to identify genes that led to accelerated lymphoma growth in the pre-clinical model by using unique Cas12a-compatible mouse whole-genome CRISPR "libraries." ...

Study advances gene-editing capabilities for cancer and medical research through genetic manipulations using Cas12a enzyme ...

CRISPR technology has revolutionized genetic testing and disease detection, offering precise, rapid, and cost-effective diagnostic solutions. This gene-editing tool has been adapted for molecular ...

Additionally, Editas Medicine management will participate in the following upcoming investor conferences in March: To access the live webcasts of Editas Medicine’s presentations, please visit the ...