There is significant crosstalk between DNA damage response (DDR ... The Transcreener HTS Assay platform helps to accelerate these efforts by providing a reliable and user-friendly biochemical ...
Analysis of DNA double strand breakage and ... Annual Review of Genetics 43, 223–249 (2009). Moore, C. W. et al. DNA damage-inducible and RAD52-independent repair of DNA double-strand breaks ...
Previous work from the team had identified a lead compound that could cross the blood brain barrier and target the DNA damage repair ... in vitro phosphorylation assays. Testing of the three ...
The study demonstrates how these proteins collaborate in so-called "hubs" to repair DNA damage. This knowledge offers opportunities to improve cancer therapies and other treatments where DNA ...