Trends in Genetics 22, 46–55 (2006). Argueso, J. L. et al. Double-strand breaks associated with repetitive DNA can reshape the genome. Proceedings of the Naitonal Academy of Sciences 105 ...

In mammalian cells, DNA double-strand breaks (DSBs) are repaired by the non-homologous end-joining (NHEJ) pathway. A key component of this repair mechanism is the DNA binding protein, Ku.

The Arnoult lab focuses on genome stability, DNA repair and telomere biology. We study the different types of pathways that cells use to repair DNA double strand breaks, and how telomeres escape these ...

To maintain the integrity of the genetic information, cells have evolved various DNA repair mechanisms. These mechanisms can detect and correct different types of DNA damage, such as base mismatches, ...

It is very bad if it acts at double-stranded DNA breaks because it can lead to the loss of all genes distal to the break. This detrimental aspect of telomerase is inhibited by the ATR kinase ...