Currently, phase zero (before-first-time-in-man ... Two study designs predominate: Studies of drug metabolism in a phenotyped panel—extensive metabolizer (EM) phenotype versus poor metabolizer ...

There are two key elements associated with successful drug development: efficacy and safety. Both depend on drug metabolism. Drug metabolism has become an integral part of the lead optimization phase ...

What is new is the ability to translate the science of cancer metabolism into a drug discovery programme that makes a difference in the clinic. “[Up to and including] Phase I of development ...