We identify drug metabolites from liver microsomes (e.g., mouse, rat, dog, and human) and in vivo studies. Identifying the unstable moieties can help guide the synthetic optimization of lead compounds ...

The supplement industry is booming—but so are serious health issues tied to taking these pills and powders. Here’s what ...

Drug-induced liver injury (DILI) is common because it can be caused by different pharmacological ... as they discuss the current understanding of the mechanisms that contribute to DILI and how ...

we assay stability in liver microsomes and perform reaction phenotyping against an array of CYP450s. Core personnel provide advice on the use of the supported methods for a wide variety of ...

Next, Shulman and his team want to use their method to test the effects of these and other metabolism-related drugs on liver ...

One such disease, nonalcoholic steatohepatitis (NASH), is characterized by dysregulated metabolism ... relevant reductions in markers of liver fat, inflammation and fibrosis (Fig.

Scientists from the University of California Davis have found that ibuprofen, a widely used painkiller, may have a bigger impact on the liver than previously thought. Their research also uncovered ...

The experimental drug efruxifermin is being ... glucose and energy metabolism, in turn reducing collagen levels found in liver scars. Shares of peer 89bio rose more than 50% after the study ...