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Many drugs show “polypharmacology,” meaning they clearly affect distinct targets. These 'off-target' profiles can be very different despite similarities in chemical structure, which is not as ...
To be useful for drug discovery, a 3-D protein structure must be in sharp focus ... computing allow researchers to do a broad sweep of chemical space that was once impossible, Abel says.
Ingestion of doses as small as 0.25mg can be fatal," states the US Drug Enforcement Agency (DEA). Getty Images It's also relatively easy to alter its chemical structure to produce similar ...
FDA recently awarded new chemical entity (NCE ... versions of previously approved drugs, such as Austedo, the only difference in the molecule’s structure is at least one hydrogen atom has ...