The mechanism of budding in the dynamin-independent pathways remains elusive; however, recent theoretical studies provide testable ideas in this area. There are numerous ways that endocytic cargo ...

This fragmentation was dependent on both the RING domain of MAPL and the presence of the mitochondrial fission GTPase dynamin-related protein-1 (DRP1). Interestingly, however, when the authors ...

In an effort to restore mitochondrial function in Parkinson’s, we targeted a key protein that controls mitochondrial dynamics called dynamin-related protein 1, or Drp1. Naturally abundant in ...

In an effort to restore mitochondrial function in Parkinson’s, we targeted a key protein that controls mitochondrial dynamics ...

The nucleoside diphosphate kinase NDK-1/NME1 promotes phagocytosis in concert with DYN-1/Dynamin. FASEB J. 2019 Oct;33(10):11606-11614. doi: 10.1096/fj.201900220R. Epub 2019 Jul 17. PubMed PMID: ...

Walden’s second most advanced program is an IND-ready small molecule that is designed to stabilize and restore the function of dynamin, an enzyme responsible for the maintenance of the cytoskeletal ...