are potent and selective drugs that inhibit influenza neuraminidase, an enzyme that promotes the release of influenza virus from infected cells and facilitates virus spread within the respiratory ...

Background: The efficacy and tolerability of the neuraminidase inhibitor zanamivir in the treatment of influenza have been established in an extensive programme of controlled clinical trials.

It suppresses the activity of the neuraminidase enzyme, which is responsible for the spread of the virus from an infected cell. • Caution should be exercised in patients with history of heart ...