Two independent studies show that ephrin-B2 controls the internalization and signaling of two types of vascular endothelial growth factor (VEGF) receptors—thereby regulating VEGF-induced ...

Unlike the Eph receptors, which were fairly uniform across subclass, the structures of the six A-subclass ephrins (ephrin-A1 to ephrin-A6) and three B-subclass ephrins (ephrin-B1 to ephrin-B3 ...

Xu K, Tzvetkova-Robev D, Xu Y, Goldgur Y, Chan YP, Himanen JP, Nikolov DB., Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ...

i.e., Ephrin A5 and A2; mammals have 8 ephrins and 13 Eph receptors Inhibitory and attractant diffusible proteins; ephrin A5: branching of axons Diffusible protein: secreted to work locally ...

When breast cancer cells test positive for estrogen receptors, it’s called estrogen receptor-positive (ER-positive) breast cancer. It means that estrogen is fueling the growth of the cancer.

Xu K, Tzvetkova-Robev D, Xu Y, Goldgur Y, Chan YP, Himanen JP, Nikolov DB. (2013). Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex ...

These receive incoming impulses from other neurones. Information from receptors passes along neurones, as electrical impulses to co-ordinators such as the central nervous system or CNS.

A novel therapeutic approach for the treatment of cerebral cavernous malformation (CCM) was established through targeting the polycomb repressive complex 1 protein CBX7. In CCM, brain endothelial ...

During my PhD I studied the generation of cell-cell repulsion downstream of the Eph receptor family of tyrosine kinases with Prof. Kate Nobes. To study the regulation of cell migration in vivo, I ...