It can be used alone or in combination with other ... For hypertension, the recommended starting dose of eplerenone is 50 mg once daily and full therapeutic effect occurs in four weeks.

In a multicenter, 8-week trial in 417 essential hypertensive patients eplerenone 50, 100, or 400 mg o.d. or 25, 50 or 200 mg b.i.d. was compared with spironolactone 50 mg b.i.d. or placebo.