5). These data show that PS1 mutations perturb neuronal calcium homeostasis, and exacerbate oxidative stress and mitochondrial dysfunction, resulting in a lowered threshold for excitotoxic ...

Background and aims: We have recently shown that Dextromethorphan is neuroprotective against excitotoxic and hyperoxic-induced brain injury. Beside its antagonistic effect on the NMDA [N-methyl-D ...